Derma Gel HBO – a new treatment approach for Atopic Dermatitis with scientific evidence

Atopic dermatitis is a highly prevalent, non-communicable, chronic skin disease and rank 15th among all non-fatal diseases with regard to disability adjusted life years, and first among all skin diseases (based on Global Burden of Disease (GBD) estimates), with the main burden in children.

Our technology in producing Derma gel: It is produced with Sac Moc Tinh technology approved by the Department of Health in Ho Chi Minh City, and used as a supportive treatment for AD management. The product’s ingredients include (a) Total Bamboo leaf extracts (50%); (b) Mixed herbal oils (olive, curcumin, coconut, sweet gourd in equal volume, 10%); (c) Vaseline (40%) (d) Skin penetration enhancement additives. For dosage and frequency, the product should be applied externally three times a day, regardless of whether it is used by adults or children. The brief process of making Derma gel includes the following steps: (i) extraction of Bambusa vulgaris leaf extract using absolute ethanol (99%), (ii) combination of the extract with mixed herbal oils (Coconut, Olive, Curcumin, Sweet Gourd) for preservation (anti-oxidation, anti-fermentation and reducing oxygen contact) as the exposure of the fresh plant material to air for 30 minutes resulting in a decrease in antioxidant activity from 10% to 44% (Barmaverain D et al.2022), and (iii) incubation at room temperature (25-28 °C) with super hydrophilic carriers as skin penetration enhancement additives, non-disclosure the name of additives, approved by Europe Union Commission Regulation No. 231 as an excipient (a pharmacologically inactive substance and food supplement), to enhance skin penetration for plant extracts with a molecular weight greater than 1 billion Daltons to penetrate human skin intracellularly through the water affinity of the super hydrophilic carriers. Human skin has unique properties such as functioning as a physicochemical barrier, which resists the penetration of many molecules. The molecular weight of a compound must be below 500 Daltons to allow skin absorption, as larger molecules cannot pass the corneal layer (Bos JD and Meinardi M.M.2000).

Our publication can be found in this link: https://www.sciencedirect.com/science/article/pii/S2667031323000763

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